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The Nanotechnology centre's history began in 1992 with the establishment of the Central Analytical Laboratory (CAL) at VSB – Technical University of Ostrava lead by professor Zdeněk Weiss. Laboratories were then equipped with the state-of-the-art apparatus purchased via the European PHARE project. Their main objective was to offer services to VSB – Technical University of Ostrava and customers from the industrial, business, and legislative sectors. In 1997, the laboratory services were accredited by the Czech Accreditation Institute; this accreditation is still being prolonged and expanded.

Simultaneously with the service activities, educational activities were also pursued – in collaboration with the Faculty of Metallurgy and Materials Engineering and the newly established Faculty of Civil Engineering – as well as scientific activities focused on clay, carbonaceous and friction materials. Therefore, the Institute of Materials Chemistry (IMACH) was established in 2003 on CAL's foundation. The first director was professor Zdeněk Weiss who led the Centre until May of 2005 when he deceased after a brief illness. The Centre's scientific activities were fully expanded with the research project MŠMT MSM6198910016 "Synthesis, Structure, and Characteristics of Nanomaterials Based on Intercalated Phyllosilicates" in 2005-2011 the results of which were very positively received.

In 2005, professor Pavla Čapková was appointed as a director. She both developed the existing activities of the Centre and realized the vision of its founder – by laying down the fundaments of the Nanotechnology centre established on February 1st, 2007, by its transformation from VÚCHEM. Since then, the activities of the Centre have been focused on preparation, characterization, and application of nanomaterials. However, the original line of work involving service, development, and research activity in chemical, phase, and structural analysis was preserved and developed further.

Research in nanotechnology was further supported by establishing the "Nanotechnology" study programme, which was developed in close collaboration with the Institute of Physics (Faculty of Mining and Geology, VSB – Technical University of Ostrava). VSB – Technical University of Ostrava was the first University in the Czech Republic to be accredited for a programme in this field; the first students entered both bachelor's – and master's study programmes in 2007. After the successful accreditation of the doctoral study programme in 2012, several students have already successfully graduated.

In 2010, professor Jaromír Pištora was appointed as a director of the Centre. He still develops the activities on which the Nanotechnology Centre was established and, simultaneously, builds new opportunities for young scientists and researchers, e.g., by supporting the "double-degree" studies in nanotechnology in cooperation with Universities and Colleges in France, USA, and Canada.